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Extensive HLA class I binding promiscuity among EBV- and HIV- derived cytotoxic T lymphocyte epitopes

✍ Scribed by Nicole Frahm; Karina Yusim; Peter Hraber; Sharon Adams; Franco Marincola; Bette Korber; Christian Brander


Book ID
116530466
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
21 KB
Volume
65
Category
Article
ISSN
0198-8859

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Extensive HLA class I allele promiscuity
✍ Nicole Frahm; Karina Yusim; Todd J. Suscovich; Sharon Adams; John Sidney; Peter 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

## Abstract Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I‐restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well‐defined viral epitopes were tested in 100