✦ LIBER ✦

Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene

✍ Scribed by Laurent Chêne; Christiane Giroud; François Desgrandchamps; Laurent Boccon-Gibod; Olivier Cussenot; Philippe Berthon; Alain Latil

Publisher: John Wiley and Sons
Year: 2004
Tongue: French
Weight: 221 KB
Volume: 111
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.20337

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✦ Synopsis

Abstract

Loss of heterozygosity (LOH) on chromosome arm 7q31 is found in many prostate tumors. Such alterations are generally associated with inactivation of tumor suppressor genes. It has been shown previously that the main region of LOH at 7q31 spans the interval between the D7S486 and D7S2460 microsatellite loci, which contains several candidate tumor suppressor genes (TSG) such as TES, CAV2, CAV1, MET, CAPZA2, ST7 and WNT2. We tested 41 human sporadic prostate tumors for 7q31 LOH by using 5 polymorphic markers overlapping the critical region and used a real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) assay to study the expression of the 7 candidate TSGs located in this genomic region. We found that CAV1, CAV2, MET and TES mRNA expression was lower in prostate tumors than in normal prostate tissues. Our immunohistochemical results and previously published data on the compartmental expression of these messenger RNAs in stromal and epithelial cells suggest that TES is the best candidate tumor suppressor gene at 7q31. © 2004 Wiley‐Liss, Inc.

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