Extension of the Rorschach–Hazlewood Theoretical Model for Spin–Lattice Relaxation in Biological Systems to Low Frequencies
✍ Scribed by Andreas Hackmann; David C. Ailion; Krishnamurthy Ganesan; Gernot Laicher; K.Craig Goodrich; Antonio G. Cutillo
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 136 KB
- Volume
- 110
- Category
- Article
- ISSN
- 1064-1866
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✦ Synopsis
The water -biopolymer cross-relaxation model, proposed by cies; accordingly, the theory in its original form cannot ex-H. E. Rorschach and C. F. Hazlewood (RH) [J. Magn. Reson. plain the low-frequency dependence of T 1 . In this paper, 70, 79 (1986)], explains the Larmor frequency dependence of T 1 we have extended the RH model to explain spin-lattice in many biological systems. However, the RH theory fails at low relaxation, including that in the rotating frame, at all Larmor Larmor frequencies. In this paper, a more general version of frequencies. the RH theory has been developed. This theory is valid at all frequencies. Use of the new expression for the spin -lattice re-BASIC RH MODEL laxation rate (1/T 1 ), earlier published experimental data in H 2 O/ D 2 O bovine serum albumin, which had been measured over a
In the RH model, the T 1 of a heterogeneous biological wide frequency range (10 kHz to 100 MHz), were fitted over the system can be considered to arise from two sources: bulk entire frequency range. The agreement between theory and the water protons (solvent phase) and macromolecular protons experimental data is excellent. Theoretical expressions for the (protein phase). Cross relaxation can cause longitudinal magrotating-frame spin -lattice relaxation rate (1/T 1r ) were also obnetization to be transferred between the two phases. The z tained.