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Extending the scope of enantiomer separation on diluted methylated β-cyclodextrin derivatives by high-resolution gas chromatography

✍ Scribed by Nowotny, H.-P. ;Schmalzing, D. ;Wistuba, D. ;Schurig, V.

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
652 KB
Volume
12
Category
Article
ISSN
0935-6304

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✦ Synopsis

High

-resolution open-tubular columns coated with solutions of heptakis(2,3,6-tri-O-methyl)-P-cyclodextrin (Phase I) or heptakis(2,6-di-O-methyl-3-O-trifluoroacetyl)-~-cyclodextrin (Phase I/) in moderately polar polysiloxanes such as OV-1701 (5% cyanopropyl/7% pheny1/88% methylpolysiloxane) and OV-225 (25% cyanopropyl/50% phenyl/25% methylpolysiloxane) are used for the gas chromatographic enantiomer separation of volatiles belonging to different classes of compounds. No derivatization procedures are necessary for most of the resolved chiral molecules. The chiral stationary phases can be operated between 25 and 1 90°C for extended periods of time. The enantiomer separation of saturated, unfunctionalized hydrocarbons clearlydemonstrates the importanceof molecularinclusion in chiral recognition using cyclodextrins for this class of compounds. The different,and in some cases complementary,selectivityof the Phases I and I/ is demonstrated.

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## Abstract The effect of dilution of the chiral stationary phase octakis (3‐O‐butyryl‐2, 6‐di‐O‐pentyl)‐γ‐cyclodextrin in the achiral polysiloxane OV–1701 on the separation factor was investigated over a wide concentration range. The loss in enantioselectivity was only negligible down to a dilutio