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Extending the range of diffusion times for regional measurement of the 3He ADC in human lungs

✍ Scribed by Chengbo Wang; G. Wilson Miller; Talissa A. Altes; Eduard E. de Lange; Gordon D. Cates Jr.; Jaime F. Mata; James R. Brookeman; John P. Mugler III

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
473 KB
Volume
59
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A stimulated‐echo‐based technique was developed to measure the regional apparent diffusion coefficient (ADC) of hyperpolarized ^3^He during a single breathhold for diffusion times of 25 ms or greater. Compared to previous methods, a substantially shorter minimum diffusion time was achieved by decoupling diffusion sensitization from image acquisition. A hyperpolarized‐gas phantom was used to validate the method, which was then tested in four healthy subjects in whom regional ADC maps were acquired with diffusion times of 50, 200, and 1500 ms and a tag wavelength of 5 or 10 mm. ADC values from healthy subjects were in good agreement with reported literature values and decreased with increasing diffusion time. Mean ADC values were ≈0.07, 0.03, and 0.015 cm^2^/s for diffusion times of 50, 200, and 1500 ms, respectively. ADC maps were generally homogeneous, with similar mean values when measured with the same parameters in different subjects. Magn Reson Med 59:673–678, 2008. © 2008 Wiley‐Liss, Inc.

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