Probing the interactions of an acyl carr
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Louise K. Charkoudian; Corey W. Liu; Stefania Capone; Shiven Kapur; David E. Can
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Article
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2011
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Cold Spring Harbor Laboratory Press
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English
β 646 KB
## Abstract The assemblyβline architecture of polyketide synthases (PKSs) provides an opportunity to rationally reprogram polyketide biosynthetic pathways to produce novel antibiotics. A fundamental challenge toward this goal is to identify the factors that control the unidirectional channeling of