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Extended high efficacy of the combination sulphadoxine-pyrimethamine with artesunate in children with uncomplicated falciparum malaria on the Benin coast, West Africa

✍ Scribed by Nahum, Alain (author);Erhart, Annette (author);Ahounou, Daniel (author);Bonou, Désiré (author);Van Overmeir, Chantal (author);Menten, Joris (author);Akogbeto, Martin (author);Coosemans, Marc (author);Massougbodji, Achille (author);D'Alessandro, Umberto (author)


Book ID
120687026
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
462 KB
Volume
8
Category
Article
ISSN
1475-2875

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The point mutations in the Plasmodium falciparum dihydrofolate reductase (dhfr) and the dihydropteroate synthase (dhps) genes that are linked to sulphadoxine-pyrimethamine (SP) resistance in vitro have been well characterised. To determine whether a few of these mutations could predict SP treatment