Patient compliance (adherence) with prescribed medication is often erratic, while clinical outcomes are causally linked to actual, rather than nominal medication dosage. We propose here a hierarchical Markov model for patient compliance. At the first stage, conditional upon individual random effects
Extended Gauss–Markov Theorem for Nonparametric Mixed-Effects Models
✍ Scribed by Su-Yun Huang; Henry Horng-Shing Lu
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 158 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0047-259X
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✦ Synopsis
The Gauss Markov theorem provides a golden standard for constructing the best linear unbiased estimation for linear models. The main purpose of this article is to extend the Gauss Markov theorem to include nonparametric mixed-effects models. The extended Gauss Markov estimation (or prediction) is shown to be equivalent to a regularization method and its minimaxity is addressed. The resulting Gauss Markov estimation serves as an oracle to guide the exploration for effective nonlinear estimators adaptively. Various examples are discussed. Particularly, the wavelet nonparametric regression example and its connection with a Sobolev regularization is presented.
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