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Expression of β-endorphin and its receptors in the spinal cord of obese-diabetic ob/ob mice

✍ Scribed by Siobhan MacDonald; Margaret E Smith; Clifford J Bailey

Book ID
117476723
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
202 KB
Volume
248
Category
Article
ISSN
0304-3940

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The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. In normal mice, chronic administration of metformin (60 mg X kg-1 X day-1 for 50 weeks) increased the number of low affinity receptors by 148%.