Expression system for recombinant human
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TunΓ§er H. Γzdamar; BirgΓΌl ΕentΓΌrk; Γzge Deniz Yilmaz; GΓΌzide ΓalΔ±k; Eda Γelik; P
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Article
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2009
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American Institute of Chemical Engineers
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English
β 328 KB
We demonstrate for the first time, an expression system mimicking serine alkaline protease synthesis and secretion, producing native form of human growth hormone (hGH) from Bacillus subtilis. A hybrid-gene of two DNA fragments, i.e., signal (pre-) DNA sequence of B. licheniformis serine alkaline pro