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Expression of Urokinase-type Plasminogen Activator (uPA), uPA Receptor, and Plasminogen Activator Inhibitor-1 in Oral Squamous Cell Carcinoma

✍ Scribed by Inoue, Yoshiko; Sugiura, Tsuyoshi; Matsuki, Ryousuke; Ishii, Kotaro; Seki, Katsuhiro; Shirasuna, Kanemitsu

Book ID: 122505509
Publisher: Wiley (John Wiley & Sons)
Year: 2007
Tongue: English
Weight: 639 KB
Volume: 4
Category: Article
ISSN: 1348-8643
DOI: 10.1016/S1348-8643(07)80010-3

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Met protein encoded by MET oncogene is the high affinity receptor for hepatocyte growth factor (HGF)/scatter factor (SF). HGF/SF has to be cleaved in its heterodimeric form by the urokinase-type plasminogen activator (uPA) to become active as a ligand for Met receptor. The expression of Met protein