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Expression of tumor suppressor gene p27 in high grade astrocytomas correlates with survival

✍ Scribed by R. Kirla; E. Salminen; H. Haapasalo; L. Talve; H. Kalimo


Book ID
117667404
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
161 KB
Volume
35
Category
Article
ISSN
0959-8049

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Low expression of p27 indicates a poor p
✍ Ruut M. Kirla; Hannu K. Haapasalo; Hannu Kalimo; Eeva K. Salminen πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 82 KB

## Abstract ## BACKGROUND Two families of tumor suppressor genes, Cip/Kip (p21, p27, and 57) and INK4 (p15, p16, p18, and p19), regulate cell proliferation and neoplastic transformation. p27 exerts its suppressor effect through cyclin E‐dependent kinase (CDK2) by inhibiting the phosphorylation of