Low expression of p27 indicates a poor p
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Ruut M. Kirla; Hannu K. Haapasalo; Hannu Kalimo; Eeva K. Salminen
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Article
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2003
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John Wiley and Sons
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English
β 82 KB
## Abstract ## BACKGROUND Two families of tumor suppressor genes, Cip/Kip (p21, p27, and 57) and INK4 (p15, p16, p18, and p19), regulate cell proliferation and neoplastic transformation. p27 exerts its suppressor effect through cyclin Eβdependent kinase (CDK2) by inhibiting the phosphorylation of