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Expression of tumor-associated antigen RCAS1 and its possible involvement in immune evasion in oral squamous cell carcinoma

โœ Scribed by T. Toyoshima; S. Nakamura; W. Kumamaru; E. Kawamura; H. Ishibashi; J-N. Hayashida; M. Moriyama; Y. Ohyama; M. Sasaki; K. Shirasuna


Book ID
111254958
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
770 KB
Volume
35
Category
Article
ISSN
0904-2512

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## RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is present in neoplastic cells, induces apoptosis of natural killer (NK)/T cells and plays a role in immune evasion. Fas ligand (FasL) is considered to have similar roles. The Epstein-Barr virus (EBV)-encoded latent membrane protein

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## Abstract ## Background. Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still