Carcinoma of the uterine cervix is a common malignancy, and many affected women, have been found to exhibit loss of heterozygosity (LOH) in the chromosome 3p region. Recent studies have localized the FHIT (fragile histidine triad) gene in this region and also demonstrated a high frequency of abnorma
Expression of truncated FHIT transcripts in cervical cancers and in normal human cells
β Scribed by Matthews, C P; Shera, K; Kiviat, N; McDougall, J K
- Book ID
- 110064882
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 634 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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Cytogenetic and molecular studies have suggested that the 3p14.2 chromosome subband contains tumor suppressor genes involved in the pathogenesis of many types of human cancers. Recently, the FHIT (fragile histidine triad) gene was identified in this part of chromosome 3 as a candidate suppressor gen