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Expression of triplicated and quadruplicated α globin genes in sheep

✍ Scribed by R. Vestri; E. Pieragostini; F. Yang; P. di Gregorio; A. Rando; P. Masina


Book ID
114712493
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
581 KB
Volume
77
Category
Article
ISSN
0007-1048

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The pathophysiology and clinical severity of ␤-thalassemia are related to the degree of ␣/non-␣-chain imbalance. A triplicated ␣-globin gene locus can exacerbate effects of excess ␣-chains caused by a defective ␤-globin gene, although this is not observed in all cases. Extensive studies on this cond