Expression of Thymidine Phosphorylase in Primary Human Renal Cell Carcinoma by ELISA Method
โ Scribed by Kinsui, Hidetoshi ;Ueda, Takeshi ;Suzuki, Hiroyoshi ;Isaka, Shigeo ;Sekita, Nobuyuki ;Komiya, Akira ;Tobe, Toyofusa ;Yamanishi, Tomonori ;Akakura, Koichiro ;Ichikawa, Tomohiko ;Igarashi, Tatsuo ;Ito, Haruo
- Book ID
- 108582178
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2002
- Tongue
- English
- Weight
- 65 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0910-5050
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## Abstract Uridine phosphorylase (UPase) and an angiogenic enzyme, thymidine phosphorylase (dThdPase) are involved in degradation of the pyrimidine nucleosides through phosphorolysis. The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in n
The purpose of the present study was to examine directly the role of thymidine phosphorylase (TP) in the sensitivity of renal cell carcinoma (RCC) to a novel fluoropyrimidine carbamate, capecitabine. TP cDNA-transfected RCC are used in these experiments to provide a basis for improved therapeutic be