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Expression of thrombomodulin, caveolin-3, and desmin on muscle fibers in neuromuscular diseases

✍ Scribed by Takahito Niiyama; Itsuro Higuchi; Ikuro Maruyama; Mitsuhiro Osame

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 668 KB
Volume: 22
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199912)22:12<1713::aid-mus15>3.0.co;2-2

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✦ Synopsis

The expression of thrombomodulin (TM) and caveolin-3 on biopsied muscle fibers from 17 patients with various neuromuscular diseases was studied immunocytochemically. We also compared the expression of TM and caveolin-3 with that of desmin, which is a marker for muscle fiber regeneration. Most TM-positive muscle fibers strongly expressed caveolin-3 and desmin. Our results suggest that TM is expressed and caveolin-3 is upregulated during the process of muscle fiber regeneration.

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