## Abstract Deletions of the short arm of chromosome 3 are often observed in a specific subset of aggressive neuroblastomas (NBs) with loss of distal 11q and without __MYCN__ amplification. The critical deleted region encompasses the locus of the von Hippel‐Lindau gene (__VHL__, 3p25). Constitution
Expression of the von Hippel-Lindau tumor suppressor gene in nonneoplastic and neoplastic lesions of the thyroid
✍ Scribed by Raoul Hinze; Carsten Boltze; Axel Meye; Hans-Jürgen Holzhausen; Henning Dralle; Friedrich-Wilhelm Rath
- Book ID
- 111638361
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 368 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1046-3976
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Communicated by Victor A. McKusick von Hippel-Lindau disease (VHL) is an inherited neoplastic disorder characterized by the development of tumors in the eyes, brain, spinal cord, inner ear, adrenal gland, pancreas, kidney, and epididymis. The VHL tumor suppressor gene was identified in 1993. Initial