Expression of the protooncogenes in psoriatic lesions

✍ Scribed by V. N. Mordovtsev; I. V. Starkov; E. R. Zabarovsky; L. L. Kisselev

• Book ID: 104763840
• Publisher: Springer-Verlag
• Year: 1988
• Tongue: English
• Weight: 541 KB
• Volume: 280
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00412681

✦ Synopsis

The expression of cellular protooncogenes in psoriatic lesions was studied. RNA isolated from involved skin of psoriatic patients was subjected to dotblot hybridization with cloned viral Ki-ras, myc, abl, fos, src, erbB, mos, sis, fes, and yes oncogenes. RNA isolated from the aortal epithelium, peripheral blood lymphocytes, and skin of the nonpsoriatic patients was used as control. The results indicate that the expression of Ki-ras, myc,fos, and abl genes is elevated in psoriatic lesions. The data of this work suggest that the activity of cellular oncogenes may play an important role in the development of psoriasis.