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Expression of the MN1–TEL fusion protein in the human UCSD/AML1 leukemic cell line

✍ Scribed by Valle, V Della; Guglielmi, L; Busson, M; Zwarthoff, E C; Berger, R; Bernard, O A

Book ID
110055944
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
87 KB
Volume
18
Category
Article
ISSN
0887-6924

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## Abstract AML1‐ETO, a fusion protein generated by the chromosomal translocation t(8;21), is frequently associated with acute myeloid leukemia (AML). In addition to blocking differentiation, AML1‐ETO is also shown to induce growth arrest in AML cells, which is unfavorable for leukemogenesis harbor