Expression of the low-affinity neurotrophin receptor, p75NTR, is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination
✍ Scribed by Steven Petratos; Michael F. Gonzales; Michael F. Azari; Mark Marriott; Rebecca A. Minichiello; Kylie A Shipham; Christos Profyris; Antonis Nicolaou; Kristy Boyle; Surindar S. Cheema; Trevor J. Kilpatrick
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 1008 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0894-1491
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✦ Synopsis
Abstract
Precursor cells have the capacity to repopulate the demyelinated brain, but the molecular mechanisms that facilitate their recruitment are largely unknown. The low‐affinity neurotrophin receptor, p75^NTR^, may be one of these regulators; however, its expression profile by oligodendroglia within the multiple sclerosis (MS) brain remains uncertain. We therefore assessed the expression profile of this receptor within 8 MS and 4 control brains. We found no evidence of expression of p75^NTR^ by mature oligodendrocytes. Instead, we demonstrated the presence of p75^NTR^ on a subgroup of NG2‐positive oligodendroglial progenitors in a periventricular plaque in one MS sample. Notably, p75^NTR^‐expressing cells were also detected within the subventricular zone (SVZ) of this brain, adjacent to the periventricular plaque. In animals with experimental demyelination we observed similar patterns of p75^NTR^ expression, initially confined to precursor cells within the SVZ, followed at later stages in the disease course by its expression amongst a subset of oligodendroglial progenitors within the corpus callosum. These data suggest that a population of precursor cells within the SVZ can be induced to express p75^NTR^ and to subsequently assume an oligodendroglial progenitor phenotype in response to demyelination in the adjacent white matter. © 2004 Wiley‐Liss, Inc.