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Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: Implications for leptin's actions

✍ Scribed by Panayoula C. Tsiotra; Vassiliki Pappa; Sotirios A. Raptis; Constantine Tsigos

Book ID
117828092
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
75 KB
Volume
49
Category
Article
ISSN
1532-8600

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The adipocyte secreted hormone leptin (OB) and its receptor (OB-R) are key regulators of mammalian body weight homeostasis. Two predominant isoforms of OB-R have been described: long form (OB-R L ) characterized as a signal transducing receptor that is highly expressed in specific nuclei of the hypo