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Expression of the human cancer/testis antigen NY-SAR-35 is activated by CpG island hypomethylation

โœ Scribed by Jin-Hyung Park; Myung-Ha Song; Chang-Hun Lee; Min-Ki Lee; Young-Min Park; Lloyd Old; Sang-Yull Lee

Book ID
106365052
Publisher
Springer Netherlands
Year
2011
Tongue
English
Weight
358 KB
Volume
33
Category
Article
ISSN
0141-5492

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Activation of human cancer/testis antige
Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation
โœ Jun Hee Lim; Sang-Pyo Kim; Edward Gabrielson; Yong Bok Park; Jong-Wook Park; Tae ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 442 KB

## Abstract Expression of the __XAGEโ€1__ antigen is restricted to germ cells of the testis and a variety of neoplastic tissues. To date, the molecular mechanism for regulating expression of this cancer/testis antigen gene has been unknown. To evaluate methylation as a potential mechanism for regula