Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma
β Scribed by Genichiro Edakuni; Eizaburo Sasatomi; Toshimi Satoh; Osamu Tokunaga; Kohji Miyazaki
- Book ID
- 114431062
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 969 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1320-5463
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mal and malignant epithelial cells and several other cell The c-met proto-oncogene encodes the tyrosine kinase types, including endothelial cells and melanocytes. 4,5 receptor for hepatocyte growth factor (HGF), a potent It has been reported that the expression of c-Met is enmitogen and motogen for
We have previously shown that rat liver epithelial cells (RLEC) transfected with and constitutively expressing transforming growth factor-Ξ± (TGF-Ξ±) have an enhanced mitogenic response to hepatocyte growth factor (HGF). In the study reported here, we examined tumor clones derived from the TGF-Ξ± trans
## Abstract The hypoxic environment in tumor is reported to play an important role in pancreatic cancer progression. The interaction between stromal and cancer cells also contributes to the malignant behavior of pancreatic cancer. In the present study, we investigated whether hypoxic stimulation af