Expression of the growth arrest-specific gene 6 (GAS6) in leukemia and lymphoma cell lines
✍ Scribed by Wilhelm Dirks; Delphine Rome; Frauke Ringel; Kathrin Jäger; Roderick A.F. MacLeod; Hans G. Drexler
- Book ID
- 114119632
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 693 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0145-2126
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## Abstract A set of growth arrest‐specific (gas) genes negatively regulated by serum has been identified. To define the role of gas genes in a model of cell proliferation in vivo we analyzed the expression of one of these genes (gas‐6) during liver regeneration after partial hepatectomy (PH). We f
The GAS1 gene product induces growth arrest through a p53-dependent mechanism. To investigate whether GAS1 is a tumor suppressor gene, we transfected GAS1-negative human tumor cells with GAS1 plasmids and analyzed growth characteristics of stable transfectants. When a constitutively expressing GAS1