For specific transduction of herpes simplex virus thymidine kinase (HSV-tk) into human small-cell lung carcinoma (SCLC) cells, we explored the 5'-flanking region (-1.1 kb) of the gastrin-releasing peptide (GRP) gene as a lung cancer-specific promoter. RT-PCR analysis demonstrated expression of GRP m
Expression of the gastrin-releasing peptide gene in carcinomas of the breast
β Scribed by A. Pagani; M. Papotti; B. Sanfilippo; G. Bussolati
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 550 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0020-7136
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β¦ Synopsis
Publication of the International Union Against Cancer Publication de I'Union Internationale Contre le Cancer
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## Abstract Gastrinβreleasing peptide (GRP) has previously been shown to be an autocrine growth factor for small cell lung cancer, and our objective in the study presented here was to determine whether GRP has a similar role in pancreatic cancer. Using ^125^IβGRP, we demonstrated binding to specifi