𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Expression of the FGFR1 gene in human breast-carcinoma cells

✍ Scribed by Jocelyne Jacquemier; José Adelaide; Patricia Parc; Frédérique Penault-Llorca; Jacqueline Planche; Odile Delapeyriere; Daniel Birnbaum

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
742 KB
Volume
59
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Fibroblast growth factors (FGF) constitute a family of at least 9 members which act through high-affinity tyrosine-kinase receptors encoded by 4 distinct genes. In humans, the FGFRl gene is located in chromosomal region 8 ~1 2 . I t s amplification and expression were examined in a panel of I10 breast carcinoma samples by Southern-and Northern-blot analyses. FGFRl was amplified in 9yo and overexpressed in about l5Yo of the tumors studied. In situ hybridization experiments were performed on tissue sections of normal breast and tumors with a high level of FGFRl expression. In both normal and tumoral tissues, FGFRl RNA was detected in the epithelial cells. Overexpression of FGFRI seems to be associated with small, welldifferentiated diploid tumors.

📜 SIMILAR VOLUMES

Transcriptional regulation of DF3 gene e
Transcriptional regulation of DF3 gene expression in human MCF-7 breast carcinoma cells
✍ Miyako Abe; Donald Kufe 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 654 KB

## Abstract The DF3 gene codes for a high molecular weight human breast tumor‐associated glycoprotein. The detection of this antigen in human milk has also suggested that its expression represents a differentiated function of mammary epithelium. The present studies have examined the regulation of D

Expression of interleukin-1β in human br
Expression of interleukin-1β in human breast carcinoma
✍ Liang Jin; Ren Qi Yuan; Alexander Fuchs; Yan Yao; Ansamma Joseph; Ralph Schwall; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB 👁 1 views

brand's factor (VWF) (a marker of endothelium), thrombospondin-1 (TSP1) (an antiadhesive and antiangiogenic glycoprotein), and tumor necrosis factor-a (TNFa)

Expression of uridine and thymidine phos
Expression of uridine and thymidine phosphorylase genes in human breast carcinoma
✍ Atsuko Kanzaki; Yuji Takebayashi; Hiroko Bando; James F. Eliason; Shin-ichi Wata 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 186 KB 👁 1 views

## Abstract Uridine phosphorylase (UPase) and an angiogenic enzyme, thymidine phosphorylase (dThdPase) are involved in degradation of the pyrimidine nucleosides through phosphorolysis. The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in n

Amplification of fgfr4 gene in human bre
Amplification of fgfr4 gene in human breast and gynecological cancers
✍ Susanna Jaakkola; Paula Salmikangas; Stella Nylund; Pentti Lehtovirta; Heli Neva 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 777 KB

We have investigated gene amplification of fibroblast growth factor receptor-4 (FGFM) gene in 30 primary breast tumor samples and 15 gynecological tumor samples. Ten percent of

Examination of POU homeobox gene express
Examination of POU homeobox gene expression in human breast cancer cells
✍ Tianru Jin; Donald R. Branch; Xiaoyun Zhang; Shangle Qi; Bruce Youngson; Paul E. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 355 KB 👁 2 views

Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines

Retinoic acid induces expression of the
Retinoic acid induces expression of the interleukin-1β gene in cultured normal human mammary epithelial cells and in human breast carcinoma lines
✍ Limin Liu; Lorraine J. Gudas 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB 👁 1 views

## Abstract Retinoic acid (RA) and its derivatives inhibit the proliferation of normal human mammary epithelial cells (HMEC) and some breast carcinoma lines by mechanisms which are not fully understood. To identify genes that mediate RA‐induced cell growth arrest, an HMEC cDNA library was synthesiz