Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
β Scribed by Cristina Tognon; Stevan R Knezevich; David Huntsman; Calvin D Roskelley; Natalya Melnyk; Joan A Mathers; Laurence Becker; Fatima Carneiro; Nicol MacPherson; Doug Horsman; Christopher Poremba; Poul H.B Sorensen
- Book ID
- 114413238
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 610 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1535-6108
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## Abstract The translocation t(12;15)(p13;q25), in which the __ETV6__ gene from chromosome 12 is rearranged with the __NTRK3__ gene from chromosome 15, has recently been identified in secretory breast carcinoma (SBC). This fusion gene was initially described in congenital fibrosarcoma and congenit
## Abstract A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the Sβphase index (SPI) was determined by the incorporation of BUdR in fresh tissue. p53 mutations were observed in 29% of the cases. T