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Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

✍ Scribed by S. J. Richardson, P. Leete, A. J. Bone, A. K. Foulis, N. G. Morgan

Book ID: 120906370
Publisher: Springer
Year: 2012
Tongue: English
Weight: 532 KB
Volume: 56
Category: Article
ISSN: 0012-186X
DOI: 10.1007/s00125-012-2745-4

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## Abstract The capsid protein VP4 was identified previously as the target of antibodies contained in plasma enhancing the coxscakievirus B4 (CV‐B4) E2‐induced production of IFN‐α by peripheral blood mononuclear cells (PBMCs). The sequence of VP4 recognized by these antibodies was investigated. Thi