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Expression of the dominant negative retinoic acid receptor in liver causes hepatic disorder in transgenic mice

✍ Scribed by Tsutsumi, Atsushi; Shiota, Goshi; Kawasaki, Hironaka


Book ID
123062320
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
191 KB
Volume
118
Category
Article
ISSN
0016-5085

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Retinoic acid receptor Ξ± dominant negati
✍ Atsushi Yanagitani; Sadako Yamada; Sakiko Yasui; Takashi Shimomura; Rie Murai; Y πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 529 KB

Although attention has focused on the chemopreventive action of retinoic acid (RA) in hepatocarcinogenesis, the functional role of RA in the liver has yet to be clarified. To explore the role of RA in the liver, we developed transgenic mice expressing RA receptor (RAR) alpha- dominant negative form