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Expression of the cytoplasmic domain of β1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway

✍ Scribed by Bindu Menon; Prasanna Krishnamurthy; Ekaterina Kaverina; Jennifer N. Johnson; Robert S. Ross; Mahipal Singh; Krishna Singh

Publisher
Springer
Year
2006
Tongue
English
Weight
536 KB
Volume
101
Category
Article
ISSN
0300-8428

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β1 integrins expression in adult rat ven
β1 integrins expression in adult rat ventricular myocytes and its role in the regulation of β-adrenergic receptor-stimulated apoptosis
✍ Catherine Communal; Mahipal Singh; Bindu Menon; Zhonglin Xie; Wilson S. Colucci; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

## Abstract We have shown that the stimulation of β‐adrenergic receptors (β‐AR) increases apoptosis in adult rat ventricular myocytes (ARVMs). Integrins, a family of αβ‐heterodimeric cell surface receptors, are postulated to play a role in ventricular remodeling. Here, we show that norepinephrine (