Expression of the basolateral Na–K–Cl cotransporter during mouse nephrogenesis and embryonic development
✍ Scribed by Gregory B. Vanden Heuvel; John A. Payne; Peter Igarashi; Bliss Forbush III
- Book ID
- 113802400
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 915 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1567-133X
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The basolateral Na ϩ /K ϩ /2Cl Ϫ cotransporter (NKCC1) has been shown to be an independent regulatory site for electrogenic Cl Ϫ secretion. The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosph
Na ϩ /K ϩ /Cl Ϫ cotransporter activity is stimulated in early G 1 phase of the cell cycle and this stimulation was shown to be an essential event in fibroblast cell proliferation. In order to elucidate further the role of the Na ϩ /K ϩ /Cl Ϫ cotransporter in cell proliferation, we overexpressed the