Expression of telomerase subunits in gastric cancer
โ Scribed by Chen Fenghua; Hu Lihua; Li Yirong; Wang Lin
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- Chinese
- Weight
- 391 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0510-9752
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Using the TRAP assay, telomerase activity was previously detected in over 90% of human pleural mesotheliomas (MMs), but not in mesothelial cell cultures (MCCs), suggesting that telomerase re-activation occurs during multi-step mesothelioma carcinogenesis. The present study determined the expression
## BACKGROUND. Telomerase activation is thought to be essential for the stabilization of telomere length, through which immortalization and oncogenesis are achieved, but little is known about the regulation of telomerase in human gastric carcinoma cells. ## METHODS. A total of 27 primary gastri
## BACKGROUND. Telomerase activation is thought to be crucial for the continued growth or progression of cancer cells. Three major subunits of human telomerase, human telomerase RNA (hTR), telomerase-associated protein (TP1), and human telomerase catalytic subunit (hTERT) have been identified rece