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Expression of TAp73 and ΔNp73 isoform transcripts in thyroid tumours

✍ Scribed by A. Ferru; S. Denis; J. Guilhot; H. Gibelin; J.M. Tourani; J.L. Kraimps; C.J. Larsen; L. Karayan-Tapon


Book ID
116442557
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
80 KB
Volume
32
Category
Article
ISSN
0748-7983

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ΔNp73α inhibits PTEN expression in thyro
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## Abstract ΔNp73 is a N‐terminally truncated p53 family member with a dominant negative function, which is upregulated in cancer. PTEN is a lipid phosphatase, which is involved in the attenuation of tyrosine kinase signaling. PTEN expression is increased by p53, and its function is blunted in seve