Expression of the multidrug resistance g
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Jay S. Wunder; Robert S. Bell; Lester Wold; Dr. Irene L. Andrulis
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Article
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1993
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Elsevier Science
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English
β 717 KB
## Abstract Resistance to combination chemotherapy remains a challenge in the treatment of osteosarcoma yet has not been studied extensively in this tumour. One mechanism of multiple drug resistance is increased expression of the multidrug resistance gene (mdr1). The level of mdr1 messenger RNA (mR