Expression of SNF1/AMP-activated protein kinase and casein kinase-1ε in different rat tissues are sensitive markers of in vivo silver nanoparticles action
✍ Scribed by D.O. Minchenko; I.V. Bozhko; T.O. Zinchenko; O.P. Yavorovsky; O.H. Minchenko
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 509 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0933-5137
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✦ Synopsis
Abstract
SNF1/AMP‐activated protein kinase (SNARK) is a member of AMPK kinases which are related to serine/threonine protein kinases. It is a molecular component of the cellular stress response. Casein kinase‐1ε is important molecular components of circadian clock system and plays a fundamental role in the metabolism at both the behavioral and molecular levels and potentially has great importance for understanding metabolic health and disease, because disturbance the circadian processes lead to developing of different pathology. We have shown that silver nanoparticles change the expression of SNARK and casein kinase‐1ε in rats in time‐dependent and tissue‐specific manner. The results of this study demonstrated that silver nanoparticles have significant effect on important regulatory mechanisms which control metabolic processes in different tissues via SNARK and casein kinase‐1ε gene expression and that these genes could be a sensitive test for detection of silver nanoparticles toxic action.