Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP
✍ Scribed by Sonja C. Reining; Annette Liesegang; Heinrich Betz; Jürg Biber; Heini Murer; Nati Hernando
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 530 KB
- Volume
- 460
- Category
- Article
- ISSN
- 0031-6768
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The recently cloned Na/Pi-cotransport system NaPi-2 is an apical membrane protein of rat proximal tubular cells and is involved in proximal phosphate reabsorption. To make the protein available for further functional/structural studies, this transport system has been expressed in Sf9 insect cells us
Renal brush border membrane sodium/phosphate (Na/P0-cotransport activity is inhibited by hormonal mechanisms involving activation of protein kinases A and C. The recently cloned rat renal Na/Picotransporter (NaPi-2) contains several protein kinase C but no protein kinase A consensus sites [17,20]. I