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Expression of Ras GTPase Isoforms in Normal and Diseased Pancreas

✍ Scribed by Kocher, Hemant M.; Senkus, Ron; Moorhead, Jane; Al-Nawab, Mashal; Patel, Ameet G.; Benjamin, Irving S.; Hendry, Bruce M.

Book ID
122894194
Publisher
S. Karger AG
Year
2005
Tongue
English
Weight
436 KB
Volume
5
Category
Article
ISSN
1424-3903

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## Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Previously, it has been shown that Indian hedgehog (Ihh) and its two signaling receptors patched (Ptc) and smoothened (Smo) are involved in the pathogenesis of chronic pancreatitis (CP) and PDAC.