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Expression of protease-activated receptor (PAR)-2, but not other PARs, is regulated by inflammatory cytokines in rat astrocytes

✍ Scribed by Elena Sokolova; Stepan Aleshin; Georg Reiser

Book ID: 111651881
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 585 KB
Volume: 60
Category: Article
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2011.12.016

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## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN