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Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis

✍ Scribed by Young S. Kim; Jari Honkaniemi; Frank R. Sharp; Martin G. Täuber


Book ID
116753117
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
681 KB
Volume
128
Category
Article
ISSN
0169-328X

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Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory effects by inducing tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and IL-6. However, the cascade of events leading to induction of cytokines by IL-18 is unclear. The aim o