In the search for new risk factors at the molecular and cellular levels, clinical data [lymph-node involvement (LN) and stage] were used and 104 squamous-cell lung carcinomas were analyzed by immuno-histochemistry for expression of cyclin D1, cyclin A, cdk2, cdk4, RB, and E2F1. The results of the un
โฆ LIBER โฆ
Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents
โ Scribed by Ku Lu; Chuan Shih; Beverly A. Teicher
- Book ID
- 105993830
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 307 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio