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Expression of Pit-1 in Nonsomatotrope Cell Lines Induces Human Growth Hormone Locus Control Region Histone Modification and hGH-N Transcription

✍ Scribed by Katherine A. Hogan; Holly S. Jefferson; Vesna A. Karschner; Brian M. Shewchuk

Book ID
116664130
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
757 KB
Volume
390
Category
Article
ISSN
0022-2836

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The proximal promoter region of the human pituitary expressed growth hormone (GH1) gene is highly polymorphic, containing at least 15 single nucleotide polymorphisms (SNPs). This variation is manifest in 40 different haplotypes, the high diversity being explicable in terms of gene conversion, recurr