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Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X‐rays

✍ Scribed by Macphail, S. H.; BanÁth, J. P.; Yu, T. Y.; Chu, E. H. M.; Lambur, H.; Olive, P. L.


Book ID
111933913
Publisher
Informa plc
Year
2003
Tongue
English
Weight
320 KB
Volume
79
Category
Article
ISSN
0955-3002

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## Background In response to DNA damage or structural alterations of chromatin, histone H2AX may be phosphorylated on __Ser__139 by phosphoinositide 3-kinase related protein kinases (PIKKs) such as __ataxia telangiectasia__ mutated (ATM), ATM-and Rad-3 related (ATR) kinase, or by DNA dependent prot