Expression of PGK-A in the Australian brush-tailed possum,Trichosurus vulpecula(Kerr), consistent with paternal X inactivation
✍ Scribed by J. L. VandeBerg; J. E. Thiel; R. M. Hope; D. W. Cooper
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 431 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0006-2928
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✦ Synopsis
An extensive survey of erythrocytes of marsupials other than kangaroos for electrophoretic variation if X-linked enzymes revealed two rare PGK-A phenotypes in the phalangerid Trichosurus vupecula and one in Trichosurus caninus. Four putatively heterozygous females expressed only the variant allelic isozyme in some tissues but expressed a trace of the normal isozyme in others. A putatively hemizygous male expressed only the variant isozyme in all tissues. The phenotypic patterns were consistent with those observed in kangaroos known to exhibit partial or complete parternal X inactivation in cells of females. Tow of the T. vulpecula were a mother and her female pouch young, further suggesting that paternal X inactivation occurs in T. vulpecula. This peculiar mechanism of dosage compensation may not be restricted to kangaroos.