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Expression of pERK and pAKT in pediatric high grade astrocytomas: Correlation with YKL40 and prognostic significance

✍ Scribed by Manila Antonelli; Maura Massimino; Isabella Morra; Maria Luisa Garrè; Marina Paola Gardiman; Francesca Romana Buttarelli; Antonietta Arcella; Felice Giangaspero

Book ID
115171638
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
542 KB
Volume
32
Category
Article
ISSN
0919-6544

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## Abstract ## BACKGROUND Two families of tumor suppressor genes, Cip/Kip (p21, p27, and 57) and INK4 (p15, p16, p18, and p19), regulate cell proliferation and neoplastic transformation. p27 exerts its suppressor effect through cyclin E‐dependent kinase (CDK2) by inhibiting the phosphorylation of