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Expression of P2X5 in lymphoid malignancies results in LRH-1-specific cytotoxic T-cell-mediated lysis

✍ Scribed by Ingrid M. Overes; Björn De Rijke; Agnes Van Horssen-Zoetbrood; Hanny Fredrix; Aniek O. De Graaf; Joop H. Jansen; J. Han J. M. Van Krieken; Reinier A. P. Raymakers; Robbert Van Der Voort; Theo M. De Witte; Harry Dolstra


Book ID
108675738
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
256 KB
Volume
141
Category
Article
ISSN
0007-1048

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Aberrant expression of the hematopoietic
✍ Ingrid M. Overes; T. Henriëtte Levenga; Johanna C. M. Vos; Agnes van Horssen-Zoe 📂 Article 📅 2008 🏛 Springer-Verlag 🌐 English ⚖ 553 KB

CD8^+^ T cells recognizing minor histocompatibility antigens (MiHA) on solid tumor cells may mediate effective graft-versus-tumor (GVT) reactivity after allogeneic stem cell transplantation (SCT). Previously, we identified LRH-1 as a hematopoietic-restricted MiHA encoded by the __P2X5__ gene. Here,