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Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig

✍ Scribed by Takehisa Saito; Zhi Jian Zhang; Masaharu Tokuriki; Toshio Ohtsubo; Ichiro Noda; Yoshiyuki Shibamori; Takehito Yamamoto; Hitoshi Saito


Book ID
117471674
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
281 KB
Volume
303
Category
Article
ISSN
0304-3940

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Functional expression of p-glycoprotein
✍ X. DeclΓ¨ves; A. Regina; J.-L. Laplanche; F. Roux; B. Boval; J.-M. Launay; J.-M. πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 164 KB πŸ‘ 2 views

Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was t