Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes
✍ Scribed by Claire Mercier; Christophe Masseguin; Françoise Roux; Jacqueline Gabrion; Jean-Michel Scherrmann
- Book ID
- 113499916
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 437 KB
- Volume
- 1021
- Category
- Article
- ISSN
- 0006-8993
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Docetaxel is one of the most widely used anticancer drugs. A major problem with docetaxel treatment, however, is the considerable interpatient variability in docetaxel exposure. Another disadvantage of the drug is that it has a very low oral bioavailability and can, therefore, only be a
Although it has been well established that the drug efflux pump P-glycoprotein (P-gp) protects the brain against the entry of cytotoxic drugs, its real in situ localization, i.e., at brain capillary endothelial cells or on astrocyte foot processes, is still controversial. The aim of this study was t