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Expression of oncoproteins in primary human non-small cell lung cancer and incidence of metastases

✍ Scribed by Manfred Volm; Peter Drings; Werner Wodrich; Gerhard Kaick

Publisher
Springer
Year
1993
Tongue
English
Weight
453 KB
Volume
11
Category
Article
ISSN
0262-0898

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✦ Synopsis

In the current study the relationship between the incidence of metastatic spread and expression (at the protein level) of various proto-oncogenes was investigated in 217 human non-small cell lung carcinomas. Tumors with an overexpression of proteins encoded by the oncogenes c-jun and c-myc showed a significantly increased formation of metastases (c-jun: P =0.008; c-myc: P=0.018). No significant correlations were found between the expression of the c-fos, c-erbB1, c-neu and c-ras products and metastatic spread.

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