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Expression of nitric oxide synthase (NOS)-2 following permanent focal ischemia and the role of nitric oxide in infarct generation in male, female and NOS-2 gene-deficient mice

✍ Scribed by Angela K. Loihl; Valerie Asensio; Iain L. Campbell; Sean Murphy

Book ID: 114004916
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 902 KB
Volume: 830
Category: Article
ISSN: 0006-8993
DOI: 10.1016/s0006-8993(99)01388-8

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## Abstract Since NO production by NOS‐2 made by astrocytes activated by proinflammatory cytokines contributes to the killing of neurons in variously damaged human brains, knowing the mechanisms responsible for NOS‐2 expression should contribute to developing effective therapeutics. The expression